Tricarboxylic acid-cycle activity in Streptomyces olivaceus.
نویسندگان
چکیده
منابع مشابه
Inactivation of the tricarboxylic acid cycle aconitase gene from Streptomyces viridochromogenes Tü494 impairs morphological and physiological differentiation.
The tricarboxylic acid (TCA) cycle aconitase gene acnA from Streptomyces viridochromogenes Tü494 was cloned and analyzed. AcnA catalyzes the isomerization of citrate to isocitrate in the TCA cycle, as indicated by the ability of acnA to complement the aconitase-deficient Escherichia coli mutant JRG3259. An acnA mutant was unable to develop aerial mycelium and to sporulate, resulting in a bald p...
متن کاملStudies on the biochemistry of streptomyces. III. Glucose catabolism in Streptomyces griseus.
The operation of the tricarboxylic acid cycle and fixation of CO2 in Streptomyces griseus has recently been demonstrated in a series of tracer studies, Gilmour et al. (1955); Butterworth et al. (1955). As to the nature of the pathways of glucose catabolism in this organism, the operation of the Embden-Meyerhof glycolytic scheme and the direct oxidative pathway were indicated by inhibition studi...
متن کاملFour further antibiotics related to olivanic acid produced by Streptomyces olivaceus: fermentation, isolation, characterisation and biosynthetic studies.
Four beta-lactam antibiotics with beta-lactamase inhibitory activity MM 22380, MM 22381, MM 22382 and MM 22383 containing the carbapenem nucleus have been isolated from a culture of Streptomyces olivaceus ATCC 31365. Fermentation conditions for their production and methods for their isolation are described. Evidence for a biosynthetic link between these compounds and the previously described ol...
متن کاملApplication of citrate as a tricarboxylic acid (TCA) cycle intermediate, prevents diabetic-induced heart damages in mice
Objective(s):Higher cellular reactive oxygen species (ROS) levels is important in reducing cellular energy charge (EC) by increasing the levels of key metabolic protein, and nitrosative modifications, and have been shown to damage the cardiac tissue of diabetic mice. However, the relation between energy production and heart function is unclear. Materials and Methods:Streptozotocin (STZ, 150 mg...
متن کاملCloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.
The antibiotics fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds, but despite their efficacy, little is known regarding their biosynthesis. Here we report the identification of the Streptomyces rubellomurinus genes required for t...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 79 شماره
صفحات -
تاریخ انتشار 1961